Investigación clínica 

Publicaciones científicas de nuestro equipo - Liderada por el Dr. Santiago Navarro Ledesma

1: Navarro-Ledesma S, Hamed-Hamed D, González-Muñoz A, Pruimboom L. Physical
Activity, Insulin Resistance and Cancer: A Systematic Review. Cancers (Basel).
2024 Feb 3;16(3):656. doi: 10.3390/cancers16030656. PMID: 38339407; PMCID:
PMC10854631.

2: Navarro-Ledesma S, Aguilar-García M, González-Muñoz A, Casas-Barragán A,
Tapia-Haro RM. Association between elasticity of tissue and pain pressure
threshold in the tender points present in subjects with fibromyalgia: a cross-
sectional study. Sci Rep. 2023 Dec 12;13(1):22003. doi:
10.1038/s41598-023-49550-y. PMID: 38086996; PMCID: PMC10716166.

3: Cuevas-Cervera M, Aguilar-Nuñez D, Aguilar-García M, García-Ríos MC,
González-Muñoz A, Navarro-Ledesma S. Patellar Tendon Elasticity and Temperature
Following after a 448 Kilohertz Radiofrequency Intervention on Active Healthy
Subjects: An Open Controlled Clinical Trial. Diagnostics (Basel). 2023 Sep
18;13(18):2976. doi: 10.3390/diagnostics13182976. PMID: 37761343; PMCID:
PMC10528375.

4: Aguilar-Núñez D, Hamed-Hamed D, Aguilar-García M, Cuevas-Cervera M, Pérez-
Montilla JJ, González-Muñoz A, Pruimboom L, Navarro-Ledesma S. Adhesive
Capsulitis of the Ankle (Frozen Ankle): An Infrequent Syndrome. Biomedicines.
2023 Sep 5;11(9):2461. doi: 10.3390/biomedicines11092461. PMID: 37760901; PMCID:
PMC10650681.

5: Hamed Hamed D, Struyf F, Pruimboom L, Navarro-Ledesma S. Efficacy of combined
strategies of physical activity, diet and sleep disorders as treatment in
patients with chronic shoulder pain. A systematic review. Front Physiol. 2023
Sep 4;14:1221807. doi: 10.3389/fphys.2023.1221807. PMID: 37731546; PMCID:
PMC10507353.

6: Mertens MG, Struyf F, Verborgt O, Dueñas L, Balasch-Bernat M, Navarro-Ledesma
S, Fernandez-Sanchez M, Luque-Suarez A, Lluch Girbes E, Meeus M. Exploration of
the clinical course and longitudinal correlations in frozen shoulder: The role
of autonomic function, central pain processing, and psychological variables. A
longitudinal multicenter prospective observational study. Musculoskelet Sci
Pract. 2023 Oct;67:102857. doi: 10.1016/j.msksp.2023.102857. Epub 2023 Sep 14.
PMID: 37725869.

7: Navarro Ledesma S, Hamed-Hamed D, González-Muñoz A, Pruimboom L.
Effectiveness of Treatments That Alter Metabolomics in Cancer Patients-A
Systematic Review. Cancers (Basel). 2023 Aug 28;15(17):4297. doi:
10.3390/cancers15174297. PMID: 37686573; PMCID: PMC10486463.

8: Mertens MG, Meeus M, Verborgt O, Girbes EL, Horno SM, Aguilar-Rodriguez M,
Dueñas L, Navarro-Ledesma S, Fernandez-Sanchez M, Luque-Suarez A, Struyf F.
Exploration of the clinical course of frozen shoulder: A longitudinal
multicenter prospective study of functional impairments. Braz J Phys Ther. 2023
Jul-Aug;27(4):100539. doi: 10.1016/j.bjpt.2023.100539. Epub 2023 Aug 23. PMID:
37639942; PMCID: PMC10474583.

9: Aguilar-Nuñez D, Cervera-Garvi P, Aguilar-Garcia M, Cuevas-Cervera M,
Gonzalez-Muñoz A, Navarro-Ledesma S. Ultrasound Strain Elastography Reliability
in the Assessment of the Plantar Fascia and Its Relationship with the Plantar
Thickness in Healthy Adults: An Intra and Interobserver Reliability Study in
Novice Evaluators. Biomedicines. 2023 Jul 20;11(7):2040. doi:
10.3390/biomedicines11072040. PMID: 37509678; PMCID: PMC10377694.

10: Casanova A, Wevers A, Navarro-Ledesma S, Pruimboom L. Mitochondria: It is
all about energy. Front Physiol. 2023 Apr 25;14:1114231. doi:
10.3389/fphys.2023.1114231. PMID: 37179826; PMCID: PMC10167337.

11: González-Muñoz A, Cuevas-Cervera M, Pérez-Montilla JJ, Aguilar-Núñez D,
Hamed-Hamed D, Aguilar-García M, Pruimboom L, Navarro-Ledesma S. Efficacy of
Photobiomodulation Therapy in the Treatment of Pain and Inflammation: A
Literature Review. Healthcare (Basel). 2023 Mar 24;11(7):938. doi:
10.3390/healthcare11070938. PMID: 37046865; PMCID: PMC10094541.

12: Mena-Del Horno S, Balasch-Bernat M, Louw A, Luque-Suarez A, Rodríguez-
Brazzarola P, Navarro-Ledesma S, Murillo C, Dueñas L, Lluch E. Is there any
benefit of adding a central nervous system-focused intervention to a manual
therapy and home stretching program for people with frozen shoulder? A
randomized controlled trial. J Shoulder Elbow Surg. 2023 Jul;32(7):1401-1411.
doi: 10.1016/j.jse.2023.02.134. Epub 2023 Mar 29. PMID: 37001795.

13: Cavaggion C, Navarro-Ledesma S, Juul-Kristensen B, Luque-Suarez A, Voogt L,
Struyf F. Reliability of coracohumeral distance and subcoracoid tendons in
subacromial pain syndrome. Sci Rep. 2023 Feb 10;13(1):2383. doi:
10.1038/s41598-023-29601-0. PMID: 36765167; PMCID: PMC9918475.

14: Navarro-Ledesma S, Aguilar-García M, González-Muñoz A, Pruimboom L, Aguilar-
Ferrándiz ME. Do Psychological Factors Influence the Elastic Properties of Soft
Tissue in Subjects with Fibromyalgia? A Cross-Sectional Observational Study.
Biomedicines. 2022 Nov 30;10(12):3077. doi: 10.3390/biomedicines10123077. PMID:
36551833; PMCID: PMC9775315.

15: Navarro-Ledesma S, Fernandez-Sanchez M, Struyf F, Luque-Suarez A.
Differences in Coracohumeral Distance Between the Symptomatic and the
Asymptomatic Shoulder in Patients With Unilateral Shoulder Pain and in Healthy
Participants: A Cross-Sectional Study. J Manipulative Physiol Ther. 2022
Sep;45(7):515-521. doi: 10.1016/j.jmpt.2022.10.004. Epub 2022 Dec 13. PMID:
36517268.

16: Mertens MG, Meeus M, Noten S, Verborgt O, Fransen E, Lluch Girbés E, Aguilar
Rodríguez M, Navarro-Ledesma S, Fernandez-Sanchez M, Luque-Suarez A, Struyf F,
Dueñas L. Understanding the clinical profile of patients with frozen shoulder: a
longitudinal multicentre observational study. BMJ Open. 2022 Nov
21;12(11):e056563. doi: 10.1136/bmjopen-2021-056563. PMID: 36410809; PMCID:
PMC9680192.

17: Navarro-Ledesma S, Carroll J, Burton P, Ana GM. Short-Term Effects of Whole-
Body Photobiomodulation on Pain, Quality of Life and Psychological Factors in a
Population Suffering from Fibromyalgia: A Triple-Blinded Randomised Clinical
Trial. Pain Ther. 2023 Feb;12(1):225-239. doi: 10.1007/s40122-022-00450-5. Epub
2022 Nov 11. PMID: 36369323; PMCID: PMC9845459.

18: Navarro-Ledesma S, Carroll J, González-Muñoz A, Pruimboom L, Burton P.
Changes in Circadian Variations in Blood Pressure, Pain Pressure Threshold and
the Elasticity of Tissue after a Whole-Body Photobiomodulation Treatment in
Patients with Fibromyalgia: A Tripled-Blinded Randomized Clinical Trial.
Biomedicines. 2022 Oct 23;10(11):2678. doi: 10.3390/biomedicines10112678. PMID:
36359198; PMCID: PMC9687325.

19: Navarro-Ledesma S, Pruimboom L, Lluch E, Dueñas L, Mena-Del Horno S,
Gonzalez-Muñoz A. The Relationship between Daily Physical Activity,
Psychological Factors, and Vegetative Symptoms in Women with Fibromyalgia: A
Cross-Sectional Observational Study. Int J Environ Res Public Health. 2022 Sep
15;19(18):11610. doi: 10.3390/ijerph191811610. PMID: 36141882; PMCID:
PMC9517117.

20: Cuevas-Cervera M, Perez-Montilla JJ, Gonzalez-Muñoz A, Garcia-Rios MC,
Navarro-Ledesma S. The Effectiveness of Intermittent Fasting, Time Restricted
Feeding, Caloric Restriction, a Ketogenic Diet and the Mediterranean Diet as
Part of the Treatment Plan to Improve Health and Chronic Musculoskeletal Pain: A
Systematic Review. Int J Environ Res Public Health. 2022 May 30;19(11):6698.
doi: 10.3390/ijerph19116698. PMID: 35682282; PMCID: PMC9180920.

21: Navarro-Ledesma S, Gonzalez-Muñoz A, García Ríos MC, de la Serna D,
Pruimboom L. Circadian Variation of Blood Pressure in Patients with Chronic
Musculoskeletal Pain: A Cross-Sectional Study. Int J Environ Res Public Health.
2022 May 26;19(11):6481. doi: 10.3390/ijerph19116481. PMID: 35682067; PMCID:
PMC9180615.

22: Struyf F, Mertens MG, Navarro-Ledesma S. Causes of Shoulder Dysfunction in
Diabetic Patients: A Review of Literature. Int J Environ Res Public Health. 2022
May 20;19(10):6228. doi: 10.3390/ijerph19106228. PMID: 35627764; PMCID:
PMC9140829.

23: Cavaggion C, Navarro-Ledesma S, Luque-Suarez A, Juul-Kristensen B, Voogt L,
Struyf F. Subacromial space measured by ultrasound imaging in asymptomatic
subjects and patients with subacromial shoulder pain: an inter-rater reliability
study. Physiother Theory Pract. 2023 Oct 3;39(10):2196-2207. doi:
10.1080/09593985.2022.2072251. Epub 2022 May 3. PMID: 35505639.

24: Perez-Montilla JJ, Cuevas-Cervera M, Gonzalez-Muñoz A, Garcia-Rios MC,
Navarro-Ledesma S. Efficacy of Nutritional Strategies on the Improvement of the
Performance and Health of the Athlete: A Systematic Review. Int J Environ Res
Public Health. 2022 Apr 1;19(7):4240. doi: 10.3390/ijerph19074240. PMID:
35409921; PMCID: PMC8998415.

25: Navarro-Ledesma S, Gonzalez-Muñoz A. Mid- and Long-Term Results Using 448
kHz Stimulation on the Elasticity of the Supraspinatus Tendon Measured by
Quantitative Ultrasound Elastographyin Badminton Professionals: Prospective
Randomized Double-Blinded Clinical Trial with Nine Months of Follow-Up. J Clin
Med. 2022 Mar 17;11(6):1664. doi: 10.3390/jcm11061664. PMID: 35329990; PMCID:
PMC8950567.

26: Navarro-Ledesma S, Gonzalez-Muñoz A, Carroll J, Burton P. Short- and long-
term effects of whole-body photobiomodulation on pain, functionality, tissue
quality, central sensitisation and psychological factors in a population
suffering from fibromyalgia: protocol for a triple-blinded randomised clinical
trial. Ther Adv Chronic Dis. 2022 Feb 21;13:20406223221078095. doi:
10.1177/20406223221078095. PMID: 35222905; PMCID: PMC8864274.

27: Navarro-Ledesma S, Gijon-Nogueron G, Reina-Martín I, Ortega-Avila AB,
Pruimboom L. Patellar and Achilles Tendon Thickness Differences among Athletes
with Different Numbers of Meals per Day: A Cross-Sectional Study. Int J Environ
Res Public Health. 2022 Feb 21;19(4):2468. doi: 10.3390/ijerph19042468. PMID:
35206655; PMCID: PMC8872291.

28: de la Serna D, Navarro-Ledesma S, Alayón F, López E, Pruimboom L. A
Comprehensive View of Frozen Shoulder: A Mystery Syndrome. Front Med (Lausanne).
2021 May 11;8:663703. doi: 10.3389/fmed.2021.663703. PMID: 34046418; PMCID:
PMC8144309.

29: Navarro-Ledesma S, Gonzalez-Muñoz A. Short-term effects of 448 kilohertz
radiofrequency stimulation on supraspinatus tendon elasticity measured by
quantitative ultrasound elastography in professional badminton players: a
double-blinded randomized clinical trial. Int J Hyperthermia.
2021;38(1):421-427. doi: 10.1080/02656736.2021.1896790. PMID: 33691576.

30: Reina-Martin I, Navarro-Ledesma S, Ortega-Avila AB, Deschamps K, Martinez-
Franco A, Luque-Suarez A, Gijon-Nogueron G. Morphological Characteristics of
Passive and Active Structures of the Foot Across Populations With Different
Levels of Physical Activity. J Sport Rehabil. 2021 Mar 3;30(6):935-941. doi:
10.1123/jsr.2020-0423. PMID: 33662932.

31: Navarro-Ledesma S, Fernandez-Sanchez M, Luque-Suarez A. Differences in
supraspinatus occupation ratio between the symptomatic, the contralateral
asymptomatic shoulder and control subjects: A cross-sectional study. Medicine
(Baltimore). 2021 Feb 12;100(6):e24734. doi: 10.1097/MD.0000000000024734. PMID:
33578621; PMCID: PMC10545080.

32: Navarro-Ledesma S, Fernandez-Sanchez M, Struyf F, Luque Suarez A.
Association of Both Scapular Upward Rotation and Scapulothoracic Muscle Lengths
With Shoulder Pain, Function, and Range of Movement. J Manipulative Physiol
Ther. 2020 Oct;43(8):824-831. doi: 10.1016/j.jmpt.2019.12.006. Epub 2020 Sep 12.
PMID: 32928568.

33: Luque-Suarez A, Martinez-Calderon J, Navarro-Ledesma S, Morales-Asencio JM,
Meeus M, Struyf F. Kinesiophobia Is Associated With Pain Intensity and
Disability in Chronic Shoulder Pain: A Cross-Sectional Study. J Manipulative
Physiol Ther. 2020 Oct;43(8):791-798. doi: 10.1016/j.jmpt.2019.12.009. Epub 2020
Aug 21. PMID: 32829946.

34: Cerón Lorente L, García Ríos MC, Navarro Ledesma S, Tapia Haro RM, Casas
Barragán A, Correa-Rodríguez M, Aguilar Ferrándiz ME. Functional Status and Body
Mass Index in Postmenopausal Women with Fibromyalgia: A Case-control Study. Int
J Environ Res Public Health. 2019 Nov 16;16(22):4540. doi:
10.3390/ijerph16224540. PMID: 31744126; PMCID: PMC6888241.

35: Lluch-Girbés E, Dueñas L, Mena-Del Horno S, Luque-Suarez A, Navarro-Ledesma
S, Louw A. A central nervous system-focused treatment approach for people with
frozen shoulder: protocol for a randomized clinical trial. Trials. 2019 Aug
13;20(1):498. doi: 10.1186/s13063-019-3585-z. PMID: 31409380; PMCID: PMC6693238.

36: Navarro-Ledesma S, Fernandez-Sanchez M, Struyf F, Martinez-Calderon J,
Miguel Morales-Asencio J, Luque-Suarez A. Differences in scapular upward
rotation, pectoralis minor and levator scapulae muscle length between the
symptomatic, the contralateral asymptomatic shoulder and control subjects: a
cross-sectional study in a Spanish primary care setting. BMJ Open. 2019 Jun
12;9(6):e023020. doi: 10.1136/bmjopen-2018-023020. PMID: 31196895; PMCID:
PMC6575639.

37: Navarro-Ledesma S, Struyf F, Falla D, Luque-Suarez A. Non-traumatic chronic
shoulder pain is not associated with changes in rotator cuff interval tendon
thickness. Clin Biomech (Bristol, Avon). 2019 Mar;63:147-152. doi:
10.1016/j.clinbiomech.2019.02.011. Epub 2019 Mar 2. PMID: 30897462.

38: García-Ríos MC, Navarro-Ledesma S, Tapia-Haro RM, Toledano-Moreno S, Casas-
Barragán A, Correa-Rodríguez M, Aguilar-Ferrándiz ME. Effectiveness of health
education in patients with fibromyalgia: a systematic review. Eur J Phys Rehabil
Med. 2019 Apr;55(2):301-313. doi: 10.23736/S1973-9087.19.05524-2. Epub 2019 Jan
28. PMID: 30698402.

39: Navarro-Ledesma S, Fernandez-Sanchez M, Luque-Suarez A. Does the pectoralis
minor length influence acromiohumeral distance, shoulder pain-function, and
range of movement? Phys Ther Sport. 2018 Nov;34:43-48. doi:
10.1016/j.ptsp.2018.08.009. Epub 2018 Aug 23. PMID: 30172060.

40: Navarro-Ledesma S, Luque-Suarez A. Comparison of acromiohumeral distance in
symptomatic and asymptomatic patient shoulders and those of healthy controls.
Clin Biomech (Bristol, Avon). 2018 Mar;53:101-106. doi:
10.1016/j.clinbiomech.2018.02.013. Epub 2018 Feb 23. PMID: 29494815.

41: Martinez-Calderon J, Zamora-Campos C, Navarro-Ledesma S, Luque-Suarez A. The
Role of Self-Efficacy on the Prognosis of Chronic Musculoskeletal Pain: A
Systematic Review. J Pain. 2018 Jan;19(1):10-34. doi:
10.1016/j.jpain.2017.08.008. Epub 2017 Sep 20. PMID: 28939015.

42: Navarro-Ledesma S, Struyf F, Labajos-Manzanares MT, Fernandez-Sanchez M,
Luque-Suarez A. Is coracohumeral distance associated with pain-function, and
shoulder range of movement, in chronic anterior shoulder pain? BMC Musculoskelet
Disord. 2017 Apr 4;18(1):136. doi: 10.1186/s12891-017-1498-0. PMID: 28376749;
PMCID: PMC5379620.

43: Navarro-Ledesma S, Struyf F, Labajos-Manzanares MT, Fernandez-Sanchez M,
Morales-Asencio JM, Luque-Suarez A. Does the acromiohumeral distance matter in
chronic rotator cuff related shoulder pain? Musculoskelet Sci Pract. 2017
Jun;29:38-42. doi: 10.1016/j.msksp.2017.02.011. Epub 2017 Mar 9. PMID: 28315580.

44: Luque-Suarez A, Navarro-Ledesma S, Petocz P, Hancock MJ, Hush J. Short term
effects of kinesiotaping on acromiohumeral distance in asymptomatic subjects: a
randomised controlled trial. Man Ther. 2013 Dec;18(6):573-7. doi:
10.1016/j.math.2013.06.002. Epub 2013 Jul 4. PMID: 23830706.

En Clínica Actium, nos enorgullece contar con un equipo de investigadores altamente capacitados y comprometidos con la generación de conocimiento científico. Nuestros expertos se dedican a realizar investigaciones de vanguardia en el campo de la medicina y la salud.

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